A Novel In Vitro Model of the Bone Marrow Microenvironment in Acute Myeloid Leukemia Identifies CD44 and Focal Adhesion Kinase as Therapeutic Targets to Reverse Cell Adhesion-Mediated Drug Resistance
Cancers - 2025, 17, 135. https://doi.org/10.3390/cancers17010135
Ladikou, Eleni E., Kim Sharp, Fabio A. Simoes, John R. Jones, Thomas Burley, Lauren Stott, Aimilia Vareli, Emma Kennedy, Sophie Vause, Timothy Chevassut, Amarpreet Devi, Iona Ashworth, David M. Ross, Tanja Nicole Hartmann, Simon A. Mitchell, Chris J. Pepper, Giles Best and Andrea G. S. Pepper
Publications
2025
Severe dynein dysfunction in cholinergic neurons exacerbates ALS-like phenotypes in a new mouse model
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1871 (1). https://doi.org/10.1016/j.bbadis.2024.167540
Fabio A. Simoes, Eleni Christoforidou, Raphaelle Cassel, Luc Dupuis and Majid Hafezparast.
2024
Patient-specific computational models predict prognosis in B cell lymphoma by quantifying pro-proliferative and anti-apoptotic signatures from genetic sequencing data
Blood Cancer Journal 14 (105). https://doi.org/10.1038/s41408-024-01090-y
Richard Norris, John Jones, Erika Mancini, Timothy Chevassut, Fabio A. Simoes, Chris Pepper, Andrea Pepper and Simon Mitchell
2024
2024
An ALS-Associated Mutation Dysregulates Microglia-Derived Extracellular MicroRNAs in a Sex-Specific Manner.
Disease Models & Mechanisms 17 (5). https://doi.org/10.1242/dmm.050638
Eleni Christoforidou, Libby Moody, Greig Joilin, Fabio A Simoes, David Gordon, Kevin Talbot, and Majid Hafezparast.
Aberrant Dynein Function Promotes TDP-43 Aggregation and Upregulation of P62 in Male Mice Harboring Transgenic Human TDP-43.
Frontotemporal Degeneration 24 (7–8): 746–55. https://doi.org/10.1080/21678421.2023.2239276
Eleni Christoforidou, Fabio A Simoes, David Gordon, Kevin Talbot, and Majid Hafezparast.
2023
Potential of Non-Coding RNA as Biomarkers for Progressive Supranuclear Palsy.
International Journal of Molecular Sciences 23 (23): 14554. https://doi.org/10.3390/ijms232314554
Fabio A. Simoes, Greig Joilin, Oliver Peters, Luisa-Sophie Schneider, Josef Priller, Eike Jakob Spruth, Ina Vogt, Okka Kimmich, Annika Spottke, and Daniel C Hoffmann.
2022
Drosophila TDP-43 Dysfunction in Glia and Muscle Cells Cause Cytological and Behavioural Phenotypes That Characterize ALS and FTLD.
Human Molecular Genetics 22 (19): 3883–93. https://doi.org/10.1093/hmg/ddt243
Diaper, Danielle C, Yoshitsugu Adachi, Luke Lazarou, Max Greenstein, Fabio A Simoes, Angelique di Domenico, Daniel A Solomon, Simon Lowe, Rawan Alsubaie, and Daryl Cheng.